Universität Kassel
  FB 10   Institute of Biology   Department of Genetics
 

Publications (since 1994)

  • Dubin, M. and Nellen, W.: Characterisation of the Dictyostelium homolog of chromatin binding protein DET1 suggests a conserved pathway regulating cell type specification and developmental plasticity. (Eukaryotic Cell, in press)

  • Dubin, M, Fuchs, J, Gräf, R., Schubert, I. and Nellen, W (2010): Dynamics of a novel centromeric histone variant CenH3 reveals the evolutionary ancestral timing of centromere biogenesis. Nucleic Acids Res. 38, 7526-7537.

  • Dubin, M. and Nellen, W. (2010): A versatile set of tagged expression vectors to monitor protein localisation and function in Dictyostelium. Gene 465, 1-8.

  • Sawarkar, R., Visweswariah, S. S., Nellen, W. and Nanjundiah, V. (2009): Histone deacetylases regulate multicellular development of the social amoeba Dictyostelium discoideum. J. Mol. Biol. 391, 833-848

  • Prevorovsky, M, Grousl, T., Stanurova, J., Rynes, J., Nellen, W., Puta, F. and Folk, P. (2009): Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division. Exp. Cell Res. 315, 1533-1547.

  • Jurkowska, R.Z., Ragozine,S., Ansbach, N., Urbanke, C., Nellen, W., Cheng, X. and Jeltsch, A. (2008): Structure and function of Dnmt3a and Dnmt3/3L nucleoprotein filaments. Nucleic Acids Res. 36(21), 6656-6663.

  • Jurkowski, T.P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. and Jeltsch, A. (2008): Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. Rna, 14, 1663-1670.

  • Li, H., Chen, Q., Kaller, M., Nellen, W., Gräf, R. and De Lozanne, A. (2008): Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases. Eukaryotic Cell, 7, 894-905.

  • Popov, C., Bliznakov, S., Boycheva, S., Milinovik, N., Apostolova, M.D., Anspach, N., Hammann, C., Nellen, W., Reithmaier, J.P. and Kulisch, W. (2008): Nanocrystalline diamond/amorphous carbon composite coatings for biomedical applications. Diamond & Related Materials 17 (2008) 882.887

  • A. Hinas, J. Reimegard, E.G.H. Wagner, W. Nellen, V. Ambros & F. Söderbom (2007): The small RNA repertoire of Dictyostelium discoideum and its regulation by components of the RNAi pathway. Nucleic Acids Res. 35, 6714-26.

  • M. Kaller, B. Földesi & W. Nellen (2007): Mitotic localisation of protein factors involved in chromosome inheritance in  Dictyostelium discoideum. Biological Chemistry, 388, 355-365. (Title page)

  • Popova, M. Kuhlmann, A. Hinas, F. Söderbom & W. Nellen (2006): HelF, a putative RNA helicase acts as a nuclear suppressor of RNAi but not antisense mediated gene silencing. Nucleic Acids Res., 34, 773-784, doi:10.1093/nar/gkj46

  • A. Jeltsch, W. Nellen & F. Lyko (2006): Two substrates are better than one: dual specificities for Dnmt2 methyltransferases. Trends Biochem Sci, 31, 306-308.

  • M. Kaller, U. Euteneuer & W. Nellen (2006): Non-redundant HP1-like proteins in Dictyostelium discoideum: different functions during vegetative growth. Eukaryotic Cell 5, 530-543.

  • W. Nellen (2006): Scanning force microscopy, scanning force spectroscopy. In: Nucleic Acids from A to Z. Edt.: S. Müller, Wiley-VCH, (in press)

  • R. Chubb, G. Bloomfield, Q. Xu, M. Kaller, A. Ivens, J. Skeöton, B. Turner, W. Nellen, G. Shaulsky, R. R. Kay, W. A. Bickmore, R. H. Singer (2006): Developmental Timing in Dictyostelium is Regulated by the Set1 Histone Methyltransferase. Developmental Biology, 292, 519-532.

  • M. Kuhlmann, B. Popova & W. Nellen (2006): RNA interference and antisense mediated gene silencing in Dictyostelium. In: Dictyostelium discoideum. Methods in Molecular Biology. Edts.: L. Eichinger and F. Rivera. Humana Press.

  • M. Kaller, W. Nellen & J. R. Chubb (2006): Chromatin Analysis and Epigenetics.  In: Dictyostelium discoideum. Methods in Molecular Biology. Edts.: L. Eichinger and F. Rivera. Humana Press.

  • Kuhlmann, B. E. Borisova, M. Kaller, P. Larsson, D. Stach, J. Na,  L. Eichinger, F. Lyko, V. Ambros, F. Söderbom, C. Hammann and W. Nellen (2005): Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi. Nucleic Acids Res. 33, 6405–6417,
    doi:10.1093/nar/gki952

  • M. Kuhlmann, B. Popova & W. Nellen (2005): RNA interference and antisense mediated gene silencing. In: Small RNAs: Analysis and Regulatory Functions. Series “Nucleic Acids and Molecular Biology”, Vol. 17, Edts.: W. Nellen and C. Hammann, Springer, ISBN: 3-540-28129-0

  • R. Przybilski, S. Gräf, A. Lescoute-Phillips, E. Westhof, W. Nellen, G. Steger, C. Hammann (2005): Hammerhead ribozymes encoded in the genome of A. thaliana. Plant Cell 17, 1877-1885.

  • T. Brodegger, A. Stockmann, J. Oberstraß, W. Nellen, and H. Follmann (2004): Novel thioredoxin targets in Dictyostelium discoideum identified by two-hybrid analysis. Interactions of thioredoxin with elongation factor 1α and yeast alcohol dehydrogenase. Biological Chemistry, 385, 1185-1192.

  • W. Nellen (2004): Scanning Force Microscopy and Scanning Force Spectroscopy of RNA. In: Handbook of Biochemistry, Wiley Publishers, Roland Hartmann , Albrecht Bindereif , Astrid Schön , Eric Westhof (Edts.), ISBN: 3-527-30826-1

  • Gräf S, Borisova BE, Nellen W, Steger G & Hammann C (2004). A database search for double-strand containing RNAs in Dictyostelium discoideum. Biological Chemistry, 385, 961-965

  • Kuhlmann, M. and Nellen, W. (2004)
    RNA-Interferenz. BIUZ 3/2004, 142-150

  • Hammann, C. and Nellen, W. (2003).
    RNA: Two in one. Angew Chem Int Ed Eng 42, 714.

  • Nellen, W. and Maniak, M. (2003): Dictyostelium: Cell culture and molecular tools.
    Encyclopedia of Life Sciences. Nature Publishing Group., http://www.els.net/

  • Y. Klaue, A. Källmann, M. Bonin, W. Nellen & M. Öhman (2003): Biochemical analysis and scanning force microscopy reveal productive and non-productive binding of ADAR2 to RNA substrates. RNA 9, 839-846

  • S. Funamoto, C. Anjard, W. Nellen & H. Ochiai (2003): cAMP dependent protein kinase regulates
    Polyspondylium pallidum development. Differentiation 71, 51-61.

  • H. Martens und W. Nellen.
    Genesilencing durch RNAi und antisense RNA.
    (2002) Biospektrum 4, 351-354.

  • M. Bonin, R. Zhu, Y. Klaue, J. Oberstrass & W. Nellen (2002):
    Analysis of RNA-RNA interaction by scanning force microscopy.
    (Nucleic Acids Res., 30, No. 16 e81)

  • J. Oberstraß, M. Bonin, Y. Klaue und W. Nellen:
    Rasterkraftmikroskopie: eine neue Sichtweise molekularer Wechselwirkungen.
    (Bioforum (2002). 3/2002, 94-96)

  • H. Martens, J. Novotny, J. Oberstrass, T.L. Steck, P. Postlethwait & W. Nellen (2002):
    RNAi in Dictyostelium: the role of RdRPs and dsRNase.
    (Mol. Biol. Cell, 13, 445-453 (2002).
    Full text available at: http://www.molbiolcell.org/content/vol13/issue2/

  • J. Novotny, S. Diegel, H. Schirmacher, A. Möhrle, M. Hildebrandt, J. Oberstrass & W. Nellen:
    Dictyostelium double stranded Ribonuclease.
    (Methods in Enzymology, 342, 193-211, 2001)

  • M. Bonin, J. Oberstrass, U. Vogt, M. Wassenegger & W. Nellen:
    Binding of IRE-BP to its cognate RNA sequence: SFM studies on a universal RNA backbone
    for the analysis of RNA-protein interaction.
    (Biol. Chem. 382, 1157-1162, 2001)
    http://www.deGruyter.de/journals/bc/abs/5800.html

  • C. Zeng, C. Anjard, G. Primpke, B. Wetterauer, S. Wille & W. Nellen:
    Interactin of gdt1 and proteinkinase A (PKA) in the growth-differentiation-transition in Dictyostelium.
    (Differentiation 67, 25-32, 2000)

  • Wagner, E.G.H., Altuvia, S. & W. Nellen:
    Regulatory RNA.
    (Encyclopedia of Life Sciences, 2000, Macmillan Reference Ltd.: http://www.els.net/)

  • M. Bonin, J. Oberstrass, Noemi Lukacs, K. Ewert, E. Oesterschulze, R. Kassing & W. Nellen:
    Determination of Preferential Binding Sites for anti-dsRNA Antibodies on Double Stranded RNA by Scanning Force Microscopy.
    (RNA 6, 563-570, 2000.)

  • C. Zeng, C. Anjard, K. Riemann, A. Konzok and W. Nellen:
    gdt1, a new signal transduction component for negative regulation of the growth-differentiation-transition in Dictyostelium discoideum.
    (Molecular Biology of the Cell 11, 1631-1643, 2000)

  • G. Primpke, V. Iassonidou, W. Nellen & B. Wetterauer:
    The role of cAMP dependent protein kinase in regulating the initiation of development of Dictyostelium discoideum.
    (Developm. Biol. 221, 101-111, 2000)

  • Anjard, C., Chang, W. T. Gross, J. and W. Nellen:
    Production and activity of spore differentiation factors (SDFs) in Dictyostelium.
    (Development 125, 4067-4075, 1998)

  • C. Anjard, C. Zeng, W.F. Loomis & W. Nellen:
    Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum.
    (Devlp. Biol. 193(2), pp 146-155, 1998)

  • Zeng, Changjiang:
    Molecular Analysis of the Growth-Differentiation-Transitition in Dictyostelium.
    Thesis, Kassel-University-Press (1998)

  • P. Oberosler & W. Nellen:
    Functional activity and developmental regulation of DdRBP1, a RNA binding protein in Dictyostelium discoideum.
    (Biol. Chem. 378, pp 1353-1360, 1997)

  • W. Nellen & C.P. Lichtenstein
    Evaluation of antisense effects.
    (in: Antisense Technology, A Practical Approach
    IRL Press, Oxford, New York, Tokyo,
    ISBN 0 19 963584 6, pp 25-38, 1997)

  • C.P. Lichtenstein & W. Nellen (editors):
    Antisense technology, A Practical Approach
    (IRL Press, Oxford, New York, Tokyo, ISBN 0 19 963584 6, 1997)

  • J. Oberstaß & W. Nellen:
    Regulating Genes with Antisense RNA
    (in: Antisense Oligodeoxynucleotides and Antisense RNA. Novel Pharmacological and Therapeutic Agents
    B. Weiss, Edt., CRC Press, Boca Raton, New York, pp 171-195, 1997)

  • Hildebrandt, M. & Nellen, W.:
    Effects of endogenous antisense RNA on RNA stability and translation in Dictyostelium. (in: D. Grierson, G. Lycette, G. Tucker, edts., Mechanisms and Applications of Gene Silencing.) pp15-20 Nottingham University Press, Nottingham, UK (1996). ISBN 1-897676-25-5

  • G. Sczakiel & W. Nellen:
    In vitro and in vivo action of antisense RNA.
    (Molecular Biotechnology 6, 7-15, 1996)

  • I. Endl, A. Konzok & W. Nellen:
    Antagonistic function of intracellular and extracellular cAMP on the expression of discoidin genes in Dictyostelium.
    (Mol. Biol. Cell 7, 17 - 24, 1996)

  • A. Kuspa, T. Dingermann & W. Nellen:
    Analysis of gene function in Dictyostelium.
    (Experientia 51, 1116 - 1123, 1995)

  • J. Blusch, S. Alexander & W. Nellen:
    Multiple signal transduction pathways regulate discoidin I gene expression in Dictyostelium discoideum.
    (Differentiation 58, 253-260, 1995)

  • M. Sadiq, M. Hildebrandt, M. Maniak & W. Nellen:
    Developmental regulation of antisense mediated gene silencing in Dictyostelium.
    (Antisense Res. & Development 4, 263-267, 1994)

  • B. Mahal & W. Nellen:
    Developmental regulation of DEAD-box proteins and cloning of putative RNA helicase genes from Dictyostelium.
    (Biol. Chem. Hoppe Seyler 375, 759-763, 1994)

  • J.W.Hawkins & W. Nellen:
    Diversification of antisense Research and Development, Review of the Ringberg Meeting, April 1994:
    Mechanisms of Antisense-mediated Gene Silencing.
    (Antisense Res. & Development 4, 127-129, 1994)

  • J. Matousek, L. Trnena, R. Oberhauser, C.P. Lichtenstein, & W. Nellen:
    dsRNA degrading nucleases are differentially expressed in tobacco anthers.
    (Biol. Chem. Hoppe-Seyler, 375, 261-269, 1994)

  • J. Blusch & W. Nellen:
    Folate responsiveness during growth and development in Dictyostelium: separate but related pathways control chemotaxis and gene regulation.
    (Mol. Microbiol. 11, 331-335, 1994)